肿瘤是危害人类健康的最大杀手,肿瘤的发病率近年来呈上升趋势,死于肿瘤的人数逐年增加。肿瘤的发生、发展不仅取决于遗传因素,同时也受到表观遗传修饰的影响。表观遗传通过启动子甲基化、组蛋白去乙酰化及非编码RNA等调控方式来实现对基因表达的调控,意味着异常的表观遗传修饰可能会参与肿瘤发生。肿瘤表观遗传学机制贯穿肿瘤发生、发展的 Cancer is the biggest killer of endangering human health. The incidence of cancer is on the rise in recent years. The number of people who die of cancer increases year by year. Tumor occurrence and development not only depend on genetic factors, but also epigenetic modification. Epigenetic regulation of gene expression through promoter methylation, histone deacetylation and non-coding RNA regulation means that aberrant epigenetic modifications may be involved in oncogenesis. Tumor epigenetic mechanisms throughout the tumor development