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自慢性肾盂肾炎患者的尿中可分离出多种细菌,但细菌检验也常可为阴性。一些报告指出,这样的患者由于经常接受抗菌素治疗,尿中可能存在细菌的L型(见本刊1974年12期封4)。尿中的溶菌酶、甘氨酸、抗体、抗菌素等可促成细菌L型的形成,同时尿中较多的钠盐,尿素和酸性环境也能阻止无细胞壁的L型裂解。有人观察,慢性肾盂肾炎之所以容易复发,与停用抗菌素后L型复原为细菌有关。作者检验了150名慢性肾盂肾炎患者的尿液。于治疗前,治疗中,出院前共验3次。尿液离心后取沉淀物接种于多种培养基,包括专门分离细菌L型的培养基,共作13,000份培养。结果自150名患者中有20例自尿液分离出L型细菌。这些培养物能在含青霉素的培养基上良好地生长。经在无抗菌素培养基上传
A variety of bacteria can be isolated from the urine of patients with chronic pyelonephritis, but bacterial tests are often negative. Some reports indicate that such patients may have L-forms of bacteria in the urine due to frequent antibiotic treatment (see Issue 4, Issue 12, Issue 4). Urine lysozyme, glycine, antibodies, antibiotics and other bacteria can promote the formation of L-form, while more urine sodium, urea and acidic environment can also prevent cell-free L-type cleavage. It was observed that the reason why chronic pyelonephritis easy to relapse, and disabled antibiotics L-type bacteria to restore. The authors examined the urine of 150 patients with chronic pyelonephritis. Before treatment, during treatment, a total of 3 times before discharge. After centrifugation, the pellet was inoculated on a variety of media, including a bacterial L-type medium, for a total of 13,000 cultures. Results Of 20 of 150 patients, L-type bacteria were isolated from the urine. These cultures can grow well on penicillin-containing media. Upload on non-antibiotic medium