自身免疫性疾病中的性别差距

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为什么妇女发生自身免疫性疾病的机率远高于男性呢?妇女在多发性硬化症(MS)和类风湿性关节炎(RA)上的发病率为男性的2~3倍,并且75%的重症肌无力为女性患者。美国实际有850万自身免疫性疾病患者,其中80%为妇女。通常,妇女对感染可产生一种显著的免疫反应,这将有助于解释为什么妇女的寿命长于男性。当面对抗原时,男性体内的T-辅助淋巴细胞会产生一种轻度的“抗炎症”混合胞质波动,即所谓的以抗体产生为主的Th-2反应,妇女的免疫系 Why women have a much higher chance of developing autoimmune disease than men? The incidence of women on multiple sclerosis (MS) and rheumatoid arthritis (RA) is two to three times that of men and 75% Muscle weakness for female patients. In fact, there are 8.5 million autoimmune diseases in the United States, of which 80% are women. In general, women have a significant immune response to infection, which will help explain why women have longer lifespans than men. When faced with antigens, T-helper lymphocytes in the males produce a mild “anti-inflammatory” mixed cytoplasmic fluctuation known as the antibody-producing Th-2 response, and the women’s immune system
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