由HBVX基因编码的X蛋白(HBx)是一种多功能蛋白,它通过与多种宿主功能蛋白直接或间接地相互作用而调节多种蛋白的功能,具有广泛的反式激活作用,而且可以通过许多复杂的途径,参与细胞凋亡,参与DNA修复调控,促进细胞周期进程,与原发性肝细胞癌的发生有着密切的关系。因此,HBx的生物学功能包括对病毒本身的复制的影响和对宿主细胞的转录、增生、转化、凋亡的调控与致瘤作用。 The X protein (HBx) encoded by the HBVX gene is a multifunctional protein that regulates the function of multiple proteins through direct or indirect interaction with a variety of host functional proteins, has extensive transactivation activity, Many complex pathways, involved in apoptosis, involved in the regulation of DNA repair, and promote cell cycle progression, and has a close relationship with the occurrence of primary hepatocellular carcinoma. Therefore, the biological function of HBx includes the impact on the replication of the virus itself and the transcription and proliferation of host cells, transformation, apoptosis and tumorigenesis.