【摘 要】
：
目的比较曲马多、罗哌卡因、吗啡三组药物用于硬膜外术后镇痛效果及对家兔胃肠运动功能的影响,探讨胃动素(MOT)、血管活性肠肽(VIP)血浆浓度与家兔胃肠运动功能的关系.方法健
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目的比较曲马多、罗哌卡因、吗啡三组药物用于硬膜外术后镇痛效果及对家兔胃肠运动功能的影响,探讨胃动素(MOT)、血管活性肠肽(VIP)血浆浓度与家兔胃肠运动功能的关系.方法健康家兔、性别不限、体重无差异(P＞0.05),喂少纤维饲料3天,清水1天.随机分为四组,其中生理盐水7只(N组),曲马多组(T组)、罗哌卡因组(R组)、吗啡组(M组)各为8只,经胃管注入美蓝2 ml,静脉注射3%戊巴比妥钠1 mi/kg,静脉采血2 ml.硬膜外穿刺置管接硬膜外镇痛泵(2 ml/h).术后1小时、4小时分别采血2ml.处死家兔,分离小肠.检测镇痛评分、美蓝运动速率及不同时点的胃动素(MOT)、血管活性肠肽(VIP).结果N组疼痛评分均数与其他三组均有显著差异(P＜0.05),其余三组镇痛效果比较无显著意义(P＞0.05);四组美蓝运动速率均数比较差异有显著意义(P＜0.05),其中R组美蓝运动速率最快,与M组和N组比较均有显著差异(P＜0.05),T组较M组比较有显著差异;各组组内MOT均数比较无显著意义(P＞0.05);各组各时点VIP测定值比较差异无显著意义(P＞0.05).结论曲马多、罗哌卡因及吗啡镇痛效果较好,曲马多,罗哌卡因对胃肠运动功能影响较小;家兔血清MOT、VIP浓度与硬膜外术后镇痛胃肠运动功能无相关性.
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