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目的探讨蛛网膜下腔出血(subarachnoid hemorrhage,SAH)患者的血清心肌酶谱水平的变化。方法选择2014年9月—2016年10月本院收治的38例SAH患者作为研究组,同期选择在本院门诊部进行体检且检查结果为健康的38名调查对象为对照组,对两组调查对象进行血清心肌酶谱检查,观察并比较两组调查对象的检查计量资料比较采用t检验,计数资料比较采用χ~2检验,P<0.05为差异有统计学意义。结果研究组患者的乳酸脱氢酶(lactic dehydrogenase,LDH)、天门冬氨酸转氨酶(aspartate transaminase,AST)及血清肌酸磷酸激酶(creatine phosphokinase,CK)[(181.4±7.6)、(27.4±4.3)、(63.2±10.0)U/L]均显著高于对照组[(165.6±4.3)、(21.4±0.7)、(38.0±2.6)U/L],差异均有统计学意义(t=11.154、8.490、15.034,均P<0.05)。结论 SAH对人体心脏损害的程度较大,患者的血清心肌酶谱会发生较大变化,有效分析SAH患者血清心肌酶谱的变化,对于患者后续的治疗有非常重要的意义。
Objective To investigate the changes of serum myocardial enzymes in patients with subarachnoid hemorrhage (SAH). Methods Thirty-eight patients with SAH admitted to our hospital from September 2014 to October 2016 were enrolled in the study. During the same period, 38 subjects who took physical examinations in our outpatient department and were healthy were selected as the control group. Subjects were examined by enzyme-linked immunosorbent assay (ELISA). The t test was used to compare the measurement data of the two groups. The count data were compared with Chi-square test. P <0.05 was considered statistically significant. Results In the study group, lactic dehydrogenase (LDH), aspartate transaminase (AST) and serum creatine phosphokinase (CK) [(181.4 ± 7.6) and (27.4 ± 4.3 ), (63.2 ± 10.0) U / L] were significantly higher than those in the control group [(165.6 ± 4.3), (21.4 ± 0.7), (38.0 ± 2.6) U / L] , 8.490,15.034, all P <0.05). Conclusions SAH can damage the human heart to a large extent, and the serum myocardial enzymes of patients will undergo great changes. Effective analysis of changes of serum myocardial enzymes in patients with SAH is of great significance for follow-up treatment.