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通过158例职业性黑变病的临床分析,发现95%以上可疑致病物归属于芳香族化合物或其混合物,以及杂环化合物两类。结构式内具有闭合的共轭体系与大多数化合物含氮原子为其共性。推测这些结构可能具有直接促进黑素代谢的作用。79%病例病前有反复发作的皮炎、瘙痒或灼痛史,以及所测25例铜蓝蛋白值非常显著高于正常值,提示本病的发生可能还与炎症、光感作用及血铜浓度升高等因素有关。
Through the clinical analysis of 158 cases of occupational melanosis, found that more than 95% of the suspicious pathogenic substances belong to the aromatic compounds or mixtures, as well as two types of heterocyclic compounds. The closed conjugate system within the formula has the same generalities as the nitrogen-containing atoms of most compounds. It is speculated that these structures may have a direct melanin metabolism promoting effect. 79% of the cases had recurrent dermatitis, pruritus or burning history, and the value of 25 cases of ceruloplasmin was very significantly higher than normal, suggesting that the occurrence of this disease may also be associated with inflammation, light perception and blood copper concentration Rise and other factors.