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目的研究分析中国地区非ST段抬高的急性冠状动脉综合征患者2年的临床特点、治疗现状及自然病程。方法作为是国际性多中心关于急性冠状动脉综合征登记试验(OASIS)的一部分,中国地区由38家中心共注册因非ST段抬高的急性冠状动脉综合征(包括不稳定心绞痛及非Q波心肌梗死)入院患者2294例,对入选患者的治疗不作任何干预,治疗处理由当地医师决定,按统一方案以填表方式记录其住院的临床特征、治疗措施以及重大事件等,并进行前瞻性的追踪记录2年。患者平均年龄63岁±8岁,男性占623%。结果898%的患者就诊时存在心电图异常,绝大部分患者为不稳定心绞痛(885%)。既往有冠心病史者562%,其中将近半数曾有心肌梗死,既往病史中高血压、糖尿病、吸烟和卒中分别为574%、183%、476%、71%。住院期间药物治疗以抗血小板药物及硝酸酯制剂的应用分别为945%、966%,β阻滞剂、钙拮抗剂、转换酶抑制剂的应用分别为675%、574%和591%。出院后药物治疗率逐渐下降,下降幅度202%~502%,随访2年时抗血小板制剂、硝酸酯制剂、β阻滞剂、钙拮抗剂、转换酶抑制剂治疗率分别为738%、694%、439%、358%、316%。2年间分别有431%、231%和82%的患者采取冠状动脉造影(CAA)、经皮冠状动脉介入治疗(PCI)、冠状动脉旁路移植术(CABG)的介入检查及干预治?
Objective To study and analyze the clinical features, treatment status and natural history of patients with non-ST segment elevation acute coronary syndrome in China. Methods As part of an international multicentre trial of acute coronary syndrome (OASIS), 38 centers in China registered co-registration of non-ST-elevation acute coronary syndromes (including unstable angina and non-Q waves Myocardial infarction) admitted to hospital in 2294 cases, the treatment of patients without any intervention, the treatment decided by the local physician, according to a unified program to fill in the form of recording the clinical characteristics of their hospitalizations, treatment measures and major events, and prospective Track record 2 years. The average age of patients 63 years ± 8 years, 623% of men. Results 898% of the patients had ECG abnormalities at the time of diagnosis. The majority of patients had unstable angina (885%). Previously, 562% of patients with coronary heart disease, of which nearly half had myocardial infarction, history of hypertension, diabetes, smoking and stroke were 574%, 183%, 476%, 71%. The application of antiplatelet drugs and nitrates in drug treatment during hospitalization were 945%, 966%, 675%, 574% and 591% for β blockers, calcium antagonists and conversion enzyme inhibitors respectively. The rate of drug treatment decreased gradually after discharge from 202% to 502%. The antiplatelet agents, nitrates, β blockers, calcium antagonists and converting enzyme inhibitors were 738% and 694% respectively at the follow-up of 2 years. , 439%, 358%, 316%. Two years later, 431%, 231% and 82% of patients underwent coronary angiography (CAA), percutaneous coronary intervention (PCI), coronary artery bypass grafting (CABG) intervention and intervention treatment?