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紫杉醇和吉西他滨 (ｇｅｍｃｉｔａｂｉｎｅ)是治疗人膀胱癌的效果肯定的新药。本研究旨在确定ｐ5 3功能存在或缺失如何影响这些药物对人膀胱癌的细胞毒效应。作者用温度敏感的 ｐ5 3(ｔｓｐ5 3)突变体转染Ｊ82人膀胱癌 (ＴＣＣ)细胞株 ,ｔｓｐ5 3突变体在 37℃时功能同突变的
Paclitaxel and gemcitabine (gemcitabine) is a new drug for the treatment of human bladder cancer. The aim of this study was to determine how the presence or absence of p5 3 function affects the cytotoxic effect of these agents on human bladder cancer. The authors used a temperature-sensitive p5 3 (tsp5 3) mutant transfection J82 human bladder cancer (TCC) cell line, tsp5 3 mutant at 37 ℃ with the same function