Water demand increases continuously with an increasing population and economic development. As a result, the difference between water supply and demand becomes a significant issue, especially in arid regions. To figure out the utilization of water resources in the arid region of northwestern China(ARNWC), and also to provide methodologies to predict the water use in future, three models were established in this study to calculate agricultural irrigation, industrial and domestic water use in the ARNWC from the late 1980s to 2010. Based on river discharges in the region, the supply and demand of water resources at the river basin level were analyzed. The results indicated that agricultural irrigation demand occupies more than 90% of the total water use in the ARNWC. Total water demand increased from 31.97 km3 in the late 1980 s to 48.19 km3 in 2010. Most river basins in this arid region were under medium and high water stress. Severe-risk river basins, such as the Shiyang river basin and the eastern part of the northern piedmont of the Tianshan Mountains, were found in this region. It was revealed that the water supply became critical from April to May, which was the season of the lowest water supply as determined by comparing monthly water consumption. As a result, the difference between water supply and demand becomes a significant issue, especially in arid regions. To figure out the utilization of water resources in the arid region of northwestern China (ARNWC ), and also to provide methodologies to predict the water use in the future, three models were established in this study to calculate agricultural irrigation, industrial and domestic water use in the ARNWC from the late 1980s to 2010. Based on river discharges in the region, the supply and demand of water resources at the river basin level were analyzed. The results indicated that agricultural irrigation demand occupies more than 90% of the total water use in the ARNWC. Total water demand increased from 31.97 km3 in the late 1980 s to 48.19 km3 in 2010. Most river basins in this arid region were under medium and high water stress. Severe-risk river basins, such as the the Shiyang river basin and the eastern part of the northern piedmont of the Tianshan Mountains, were found in this region. It was revealed that the water supply became critical from April to May, which was the season of the lowest water supply as determined by Provisional monthly water consumption.