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内皮素（ET）是一种作用最强、持续最久的缩血管21肽，在研究肾脏病进展的病理过程中，对ET所起的作用已广为重视。文献报道的ET亦为TE－1活性最强l’］。本文对60例不同阶段慢性肾病患者的ET－1含量及尿毒症患者在血液透析（HD）和血液透析滤过（HDF）前后ET－1的变化进行了观
Endothelin (ET) is the most potent and long-lasting vasoconstrictive 21 peptide. The role of endothelin (ET) in the study of the pathogenesis of nephropathy has received a great deal of attention. ET reported in the literature is also the strongest TE-1 l ’]. In this paper, 60 cases of patients with different stages of chronic kidney disease ET-1 content and uremia in patients with hemodialysis (HD) and before and after hemodialysis (HDF) ET-1 changes were observed