镍螯合物2与多种取代的硼酸/硼酸酯3通过Suzuki 偶联反应, 制备具有多种取代的镍螯合物4, 通过氢化、水解两步反应合成α-取代β-氨基酸及其衍生物。该合成方法操作简单, 条件温和, 适用于α-取代-β-氨基酸及其衍生物的大规模制备。 Nickel chelate 2 and a variety of substituted boric acid / boric acid ester 3 by Suzuki coupling reaction to prepare a variety of substituted nickel chelate 4, by hydrogenation, hydrolysis two-step synthesis of α-substituted β-amino acids and its derivative. The synthesis method is simple, mild conditions, suitable for large-scale preparation of α-substituted-β-amino acids and their derivatives.