论文部分内容阅读
采用大鼠全脑缺血再灌注损伤模型，观察缺血前后应用聚合牛血红蛋白（PBHb）对脑组织兴奋性氨基酸（EAA）递质和钙代谢的影响。结果显示：与缺血再灌组和白蛋白对照组相比，脑保护PBHb组能明显减少谷氨酸（Glu）释放，而脑复苏PBHb组此作用不显著。脑保护及复苏PBHb组均能有效地抑制钙超载的发生。上述结果提示PBHb能通过减少EAA释放等途径来阻断钙超载发生，在脑保护及复苏中发挥良好作用。
The model of global cerebral ischemia-reperfusion injury in rats was used to observe the effects of PBHb on the neurotransmitter amino acid (EAA) transmitter and calcium metabolism in brain tissue before and after ischemia. The results showed that compared with the ischemia reperfusion group and the albumin control group, the brain protection PBHb group could significantly reduce the release of glutamate (Glu), while the brain resuscitation PBHb group this effect was not significant. Brain protection and recovery PBHb group can effectively inhibit the occurrence of calcium overload. The above results suggest that PBHb can block the occurrence of calcium overload by reducing the release of EAA and play a good role in brain protection and recovery.