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目的:对比不同临床类型冠心病与非冠心病患者血浆脑钠肽浓度差异,并分析与肌钙蛋白T的相关性,探讨其临床意义。方法:106例经冠状动脉造影证实的冠心病患者,包括急性心肌梗死(AMI)28例,不稳定型心绞痛(UAP)36例,稳定型心绞痛(SAP)42例。12例非冠心病者作为对照组。检测AMI患者发病24小时内及其他患者入院时的血浆BNP浓度,同时测定AMI患者的肌钙蛋白T(TnT),比较不同组别BNP的差异以及AMI组BNP与TnT的相关性。结果:对照组、SAP组、UAP组、AMI组的血浆BNP浓度分别为(38.15±11.26)pg/ml,(41.92±13.37)pg/ml,(308.54±97.34)pg/ml,(601.29±162.63)pg/ml,UAP组、AMI组与对照组、SAP组,AMI组与UA组差异具有统计学意义(P均<0.001)。AMI组BNP与TnT浓度呈正相关(P<0.001)。结论:不同临床类型冠心病患者的血浆BNP浓度存在差异,与心肌坏死的程度相关。
Objective: To compare the plasma concentration of brain natriuretic peptide in patients with different clinical types of coronary heart disease and non-coronary heart disease, and to analyze the correlation with troponin T and to explore its clinical significance. Methods: A total of 106 patients with coronary artery disease confirmed by coronary angiography, including 28 cases of acute myocardial infarction (AMI), 36 cases of unstable angina pectoris (UAP) and 42 cases of stable angina pectoris (SAP). Twelve non-CHD patients served as control group. Plasma BNP levels were measured within 24 hours of onset of AMI and other patients at hospital admission. Troponin T (TnT) was also measured in patients with AMI. BNP levels in different groups were compared with those in AMI patients. Results: Plasma BNP concentrations in control, SAP, UAP and AMI groups were (38.15 ± 11.26) pg / ml, (41.92 ± 13.37) pg / ml, (308.54 ± 97.34) pg / ml and (601.29 ± 162.63 ) pg / ml. There was significant difference between UAP group, AMI group and control group, SAP group, AMI group and UA group (all P <0.001). There was a positive correlation between BNP and TnT concentrations in AMI group (P <0.001). Conclusion: The plasma BNP levels in patients with different clinical types of coronary heart disease are different, which are related to the degree of myocardial necrosis.