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利用预乳化乳液法制备了不同单体配比的聚(甲基丙烯酸甲酯-co-甲基丙烯酸-co-甲基丙烯酸羟乙酯)(P(MMA-co-MAA-co-HEMA))微凝胶分散液;采用透射电子显微镜、动态光散射仪研究了微凝胶的微观形态、粒径大小及其溶胀率;利用试管倒转法对微凝胶分散液的凝胶化相转变行为进行了研究,借助椎板流变仪考察了所形成胶态凝胶的储能模量与单体配比、微凝胶分散液浓度和温度的关系.结果表明,所制备的微凝胶的数均粒径为90 nm左右,当MMA与MAA的投料质量不变时,随着HEMA含量的增加,分散液凝胶化所需的临界最小浓度增大,临界最大pH值减小,胶态凝胶的储能模量增加.当保持单体MMA与HEMA的投料质量不变时,随着单体MAA投料质量的增多,微凝胶的数均粒径和溶胀率增大,胶态凝胶的储能模量先升高后降低;当MAA占单体总摩尔数的25%时,浓度为15 wt%的微凝胶分散液在扫描频率为100 rad/s时,胶态凝胶的储能模量最高可达2×104Pa.这类微凝胶分散液在组织工程支架材料方面有潜在的应用价值.
The poly (methyl methacrylate-co-methacrylic acid-co-hydroxyethyl methacrylate) (P (MMA-co-MAA-co-HEMA) The microgel morphology, particle size and swelling rate of the microgel were studied by transmission electron microscopy and dynamic light scattering (DLS). The gelation phase transition of the microgel dispersion was investigated by the tube inversion method The relationship between the storage modulus and the monomer ratio, the concentration and the temperature of the microgel dispersion was investigated by means of a laminar rheometer.The results showed that the microgels prepared When the mass of MMA and MAA is constant, with the increase of HEMA content, the critical minimum concentration required for gelation of the dispersion increases, the critical maximum pH decreases, The storage modulus of plastic increases.When the feed quality of monomer MMA and HEMA remain the same, the number average particle size and swelling rate of microgel increase with the increase of feed mass of monomer MAA, Of the storage modulus first increased and then decreased; when the MAA accounted for 25% of the total number of monomers, the concentration of 15 wt% of the microgel dispersion at a scanning frequency of 100 rad / s, the storage modulus of colloidal gels up to 2 × 104Pa. Such microgel dispersions in tissue engineering scaffolds have potential applications.