慢性肾衰竭患者有异常的胃肠道激素改变,以血清中胆囊收缩素(CCK)这一强力胰腺外分泌刺激剂和胰腺分泌抑制剂如胰升糖素和胰腺多肽的浓度升高为特征。然而,此种激素改变对胰腺功能的影响尚不清楚。为了评价究竟是胰腺分泌刺激剂还是抑制剂起主要作用,以及证明这些激素是否对胰腺具有营养作用,作者对8例严重肾衰竭患者和8例年龄、性别配对的正 Patients with chronic renal failure have abnormal gastrointestinal hormonal changes characterized by elevated concentrations of cholecystokinin (CCK), a potent pancreatic exocrine stimulator, and pancreatic secretion inhibitors such as glucagon and pancreatic polypeptide. However, the effect of this hormone change on pancreatic function remains unclear. In order to assess whether pancreatic secretion stimulating agents or inhibitors play a major role, and to prove whether these hormones have nutritional effects on the pancreas, the authors of eight patients with severe renal failure and eight age and sex are positive