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切开消化道的手术往往伴有伤口的细菌污染和术后伤口感染。业已充分证明,在许多普通外科手术时用单剂全身性抗生素能预防此种感染,但迄今尚无关于食道切除时这一方法的效果的资料。本文作者报告对可能作食道切除术的61例患者作随机双盲研究。患者于诱导麻醉后立即肌肉注射羟苄四唑头孢菌素甲酸酯(Ccfamandole nafate)1克或安慰剂。在整个手术期间每小时采集一次血标本以测定抗生素浓度,且从食道和任何其他曾切开的内脏以及所有伤口用拭子采取标本作细菌学检查。
Incision of the digestive tract surgery is often accompanied by bacterial contamination of wounds and postoperative wound infection. It has been well established that with a single dose of systemic antibiotics to prevent such infections during many common surgical procedures, there is no information available on the efficacy of this method at the time of esophagectomy. The authors report a randomized, double-blind study of 61 patients who may have undergone esophagectomy. Patients were intramuscularly injected with 1 gram of CTCA or placebo immediately after induction of anesthesia. Blood samples were collected hourly throughout the procedure to determine antibiotic concentrations and swabs were taken for bacteriological examination from the esophagus and any other incised organs and all wounds.