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前列腺癌是威胁中老年男性健康的常见肿瘤。随着人民生活水平的提高和人均寿命的延长,我国前列腺癌的发病率和死亡率有逐年上升的趋势。在前列腺癌的早期,去势或抗雄激素治疗有效,约18个月后,前列腺癌会进展成为去势阻抗型,目前没有治愈的疗法~([1])。近年的研究表明,儿茶酚胺类激素激活肾上腺素能受体(AdR),通过多种信号传导方式和机制在前列腺癌的发生与发展过程中起作用~([2-5])。服用
Prostate cancer is a common cancer that threatens the health of middle-aged and elderly men. With the improvement of people’s living standards and the extension of average life expectancy, the incidence and mortality of prostate cancer in our country have been increasing year by year. In the early stages of prostate cancer, castration or anti-androgen therapy is effective, and after about 18 months, prostate cancer will progress to become castrate-resistant and there is currently no cure for this disease (1). Recent studies have shown that catecholamine hormones activate the adrenergic receptor (AdR) and play a role in the development and progression of prostate cancer through a variety of signaling pathways and mechanisms (2-5). Take