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目的分析支气管哮喘(哮喘)合并阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者的相关临床特点,探讨阻塞性睡眠呼吸暂停低通气综合征对合并有哮喘患者肺通气功能的影响。方法 121例支气管哮喘患者检测出合并OSAHS患者87例,随机分为组1(43例)和组2(44例),不伴OSAHS的34例为组3。组1采用常规哮喘药物治疗的同时加用夜间持续正压通气(CPAP)治疗。组2、组3给予常规哮喘药物治疗。观察三组治疗前后症状、肺功能的变化。结果治疗后组1、组3的哮喘症状控制程度及肺功能指标均高于组2(P<0.05)。组2各项肺通气功能指标在治疗后与治疗前比较差异无统计学意义(P>0.05)。组1第1秒用力呼气容积(FEV1)、最大呼气流量(PEF)及PEF变异率较组2明显改善,差异有统计学意义(P<0.05或P<0.01),治疗后组2、组3肺功能比较差异有统计学意义(P<0.05或P<0.01)。结论支气管哮喘伴有OSAHS患者病情不易控制,伴有OSAHS的哮喘患者常规治疗方案中加用夜间CPAP辅助治疗,可显著改善患者的肺通气功能,值得在临床推广。
Objective To analyze the clinical features of patients with bronchial asthma (asthma) complicated with obstructive sleep apnea-hypopnea syndrome (OSAHS) and to investigate the effect of obstructive sleep apnea-hypopnea syndrome on pulmonary ventilation in patients with asthma. Methods A total of 87 patients with OSAHS were detected in 121 patients with bronchial asthma. They were randomly divided into group 1 (43 cases) and group 2 (44 cases), and 34 cases without OSAHS were group 3. Group 1 was treated with conventional asthma medications plus nighttime continuous positive airway pressure (CPAP). Group 2, Group 3 given conventional asthma medication. Three groups were observed before and after treatment of symptoms, changes in lung function. Results After treatment, the control of asthma symptoms and the indexes of lung function in group 1 and group 3 were higher than those in group 2 (P <0.05). There was no significant difference in the pulmonary function indexes of group 2 between before and after treatment (P> 0.05). The FEV1, PEF and PEF variability in group 1 were significantly improved compared with group 2 (P <0.05 or P <0.01). After treatment, the rates of FEV1, Group 3 lung function difference was statistically significant (P <0.05 or P <0.01). Conclusion The patients with bronchial asthma accompanied with OSAHS are not easy to control the disease. The routine CPAP with OSAHS in patients with asthma can improve the pulmonary ventilation function, which is worthy of clinical promotion.