1969年Beiger首先描述一组病人在肾小球系膜中有IgA的局部沉积,而病人无全身性疾病。大多数病人有正常肾功能伴有肉眼血尿或镜下血尿和轻度蛋自尿。肾脏组织学典型改变为局灶性增殖。后有人命名为Berger’s病,临床常称之为良性反复性血尿。虽然所有年龄都可发生,但更常见于儿童。McCoy等认为虽然在IgA系膜沉积的同时可有IgG和/或IgM的局部沉积,但IgA是唯一持续存在于 Beiger first described in 1969 a group of patients in the glomerular mesangial deposition of IgA, and the patient without systemic disease. Most patients have normal renal function with gross hematuria or microscopic hematuria and mild egg urination. Renal histology typically changes to focal proliferation. After someone named Berger’s disease, clinically known as benign and recurrent hematuria. Although all ages can occur, it is more common in children. Although McCoy et al. Suggest that there may be localized deposition of IgG and / or IgM at the same time as IgA mesangial deposition, IgA is the only one that persists in