目的观察山莨菪碱外用按摩治疗新生儿硬肿症的治疗效果。方法119例新生儿硬肿症患儿随机分成两组,治疗组65例,对照组54例。两组均给予保暖复温、控制感染、补液及供给足够的热量、纠正器官功能紊乱等治疗,治疗组加用山莨菪碱外用按摩治疗。结果治疗组硬肿变软时间与硬肿消退时间均比对照组短,t值分别为3.667、5.568,P<0.01,差异有统计学意义。治疗组疗效优于对照组,χ2=4.35,P<0.05,两组比较差异有统计学意义。治疗组死亡率3.1%,对照组死亡率14.8%。治疗组未见明显不良反应。结论山莨菪碱外用按摩治疗新生儿硬肿症不仅可使硬肿较早变软,而且可缩短病程,提高治疗效果,降低死亡率。其操作方法简便、经济、安全、实用性强,值得在临床中推广。 Objective To observe the therapeutic effect of Anisodamine topical massage on neonatal sclerosing disease. Methods 119 cases of neonatal scleroderma were randomly divided into two groups, 65 cases in the treatment group and 54 cases in the control group. Both groups were given warm rewarming, infection control, rehydration and supply enough calories to correct organ dysfunction and other treatment, the treatment group plus anisodamine topical massage treatment. Results In the treatment group, the time of soft swelling and the regression of sclerodema were shorter than those in the control group, with t values ​​of 3.667 and 5.568 respectively (P <0.01). The difference was statistically significant. Treatment group than the control group, χ2 = 4.35, P <0.05, the difference between the two groups was statistically significant. The treatment group mortality rate of 3.1%, the control group mortality rate of 14.8%. No significant adverse reactions in the treatment group. Conclusion Anisodamine topical massage for the treatment of neonatal sclera not only makes the sclerosis soften earlier, but also shorten the course, improve the therapeutic effect and reduce the mortality rate. The operation method is simple, economical, safe and practical, it is worth to be popularized in the clinic.