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1996年1月,由中国医学科学院基础医学研究所刘德培、梁植权、黄粤、冯东晓、纪新军等15人,在国家杰出青年科学基金及国家自然科学基金重大项目资助下进行了研究。 α与β珠蛋白基因的表达调控,对我国常见的遗传病一地中海贫血的防治具有重要意义。研究以组建α与β珠蛋白基因簇的转基因鼠模型为切入点,进行了研究。 建立了细菌人工染色体(BAC)介导的含完整人α-珠蛋白基因簇(110kb)转基因鼠的模型,包括3个含
In January 1996, 15 people, including Liu Depei, Liang Zhiguen, Huang Yue, Feng Dongxiao and Ji Xinjun, from the Institute of Basic Medical Sciences of Chinese Academy of Medical Sciences under the auspices of the National Outstanding Youth Science Foundation and the National Natural Science Foundation of China. α and β-globin gene expression regulation, is a common genetic disease prevention and treatment of thalassemia major. In this study, a transgenic mouse model of α and β globin gene cluster was established as a breakthrough point. A Bacterial Artificial Chromosome (BAC) -mediated model of intact human α-globin gene cluster (110kb) transgenic mice was established including 3