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为探讨内分泌紊乱可能引起有正常月经周期妇女不育的可能性,对48例长期不能解释的一年半至十年半不育的妇女进行了研究。自从发现雌激素在垂体Lactotropes的控制催乳素合成的遗传密码以来,研究了这些病人的雌二醇排卵前高峰和血清中异构催乳素B的水平之间的可能联系。异构催乳素B是从羊水中分离出来的,并在特异的同种双抗体放射免疫分析中以碘化异构催乳素作为示踪物和参考激素。用此种放射免疫分析系统在病人的整个周期内
To investigate the possibility that endocrine disorders may cause infertility in women with normal menstrual cycles, 48 women with a long period of unexplained one and a half to ten and a half years of infertility were studied. Since the estrogen was found to control the genetic code for prolactin synthesis in the pituitary Lactotropes, a possible link between the peak pre-ovulation estrogen in these patients and the level of pro-isobalamin B in serum was studied. Heterogeneous prolactin B was isolated from amniotic fluid and iodinated heterogeneous prolactin was used as a tracer and reference hormone in a specific allo-antibody radioimmunoassay. With this radioimmunoassay system throughout the patient’s life cycle