Wind loads are key considerations in the structural design of large-span structures since wind loads can be more important than earthquake loads, especially for large flexible structures. The analysis of wind loads on large span roof structures (LSRS) requires large amounts of calculations. Due to the com- bined effects of horizontal and vertical winds, the wind-induced vibrations of LSRS are analyzed in this pa- per with the frequency domain method as the first application of method for the analysis of the wind re- sponse of LSRS. A program is developed to analyze the wind-induced vibrations due to a combination of wind vibration modes. The program, which predicts the wind vibration coefficient and the wind pressure act- ing on the LSRS, interfaces with other finite element software to facilitate analysis of wind loads in the de- sign of LSRS. The effectiveness and accuracy of the frequency domain method have been verified by nu- merical analyses of practical projects. Wind loads are key considerations in the structural design of large-span structures since wind loads can be more important than earthquake loads, especially for large flexible structures. The analysis of wind loads on large span roof structures (LSRS) requires large amounts of calculations. Due to the com- bined effects of horizontal and vertical winds, the wind-induced vibrations of LSRS are analyzed in this pa- per with the frequency domain method as the first application of method for the analysis of the wind re- sponse of LSRS. A program is developed to analyze the wind-induced vibrations due to a combination of wind vibration modes. The program, which predicts the wind vibration coefficient and the wind pressure act- ing on the LSRS, interfaces with other finite element software to facilitate analysis of wind loads in the de- sign of LSRS. The effectiveness and accuracy of the frequency domain method have been verified by nu- merical analyzes of practical projects.