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采用氨基清除树脂辅助合成方法,由6-氨基-7-氟-4-取代基-3(4H)-酮与取代邻苯二甲酸酐在冰醋酸中加热反应制备了2-(7-氟-3-氧-3,4-2H-苯并[b][1,4]噁嗪-6-基)异吲哚-1,3-二酮类化合物,纯度86%~95%,其结构经1HNMR,IR和MS表征。
Amino-scavenging resin-assisted synthesis was used to prepare 2- (7-fluoro-benzocyclohexylamino) -7-fluoro-4-substituted-3 (4H) -one by reaction with substituted phthalic anhydride in glacial acetic acid. 3-oxo-3,4-2H-benzo [b] [1,4] oxazin-6-yl) isoindole-1,3-dione with a purity of 86% to 95% 1HNMR, IR and MS characterization.