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目的 研究FHIT基因表达与人肺癌临床病理生理特征和预后的关系 ,探讨FHIT基因在人肺癌发生、发展过程中的可能作用。方法 应用免疫组化法检测了 1 66例肺癌组织标本及其癌旁肺组织和 37例肺良性病变组织中FHIT基因的表达水平。结果 肺癌组织中FHIT基因表达阳性率 (63 .0 3 %± 2 6 .41 % )显著低于癌旁组织 (83 .74%± 1 7.46 % ) ,而癌旁组织又显著低于肺良性病变组织 (92 .98%± 5 .56 % ) (P <0 .0 1 ) ;肺癌组织中FHIT基因表达水平降低与肺癌组织学类型、细胞分化程度 ,患者P TNM分期、淋巴结转移程度存在相关性 (P <0 .0 5) ;吸烟组肺癌患者的肺癌组织中FHIT基因表达阳性率 (55 .1 4 %± 2 7.55 % )明显低于非吸烟组 (71 .93%± 2 2 .0 5 % ) (P <0 .0 1 ) ;FHIT基因低表达组肺癌患者的术后长期生存率显著低于高表达组 (P <0 .0 5)。结论 FHIT基因的表达下降可能与肺癌的发生、发展过程有关。吸烟是导致肺癌患者FHIT基因表达下降的重要原因之一。
Objective To investigate the relationship between FHIT gene expression and clinical pathophysiological characteristics and prognosis in human lung cancer and to explore the possible role of FHIT gene in the development and progression of human lung cancer. Methods Immunohistochemistry was used to detect the expression of FHIT gene in 166 lung cancer specimens and their paracancer lung tissues and 37 benign lung lesions. Results The positive rate of FHIT gene expression in lung cancer tissues was significantly lower than that in adjacent non-cancerous tissues (63 .0 3% ± 2 6 .41% vs 83. 74% ± 1 7.46%, P <0.01) (92.98% ± 5.56%) (P <0.01). The decrease of FHIT gene expression in lung cancer correlated with histological type, cell differentiation, P TNM stage and lymph node metastasis (P <0.05). The positive rate of FHIT gene expression in lung cancer patients (55.1 4% ± 2 7.55%) in smokers with lung cancer was significantly lower than that in non-smokers (71.93% ± 2.25 %) (P <0.01). The long-term survival rate of lung cancer patients with low FHIT expression was significantly lower than that of high expression lung cancer patients (P <0.05). Conclusions The decrease of FHIT gene expression may be related to the occurrence and development of lung cancer. Smoking is one of the important reasons leading to the decrease of FHIT gene expression in lung cancer patients.