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氯氮平引起的粒细胞缺乏及其他严重副反应,国内外已屡有报道。但该药所致的全身皮肤粘膜广泛性出血的病例报道甚少。现报告如下:住院号6568,男,18岁,学生。因行为怪异,情绪不稳,打骂父母2年于1992年4月18日住院治疗。既往无药物治疗史。入院时查心、脑电图正常,WBC6.8×10~9/L、N0.76、L0.24。躯体及神经系统检查无异常。诊断精神分裂症。单用氯氮平系统治疗。
Clozapine caused by agranulocytosis and other serious side effects, has been repeatedly reported at home and abroad. However, the drug caused by extensive skin and mucous membrane bleeding cases rarely reported. The report is as follows: Hospital number 6568, male, 18 years old, student. Due to strange behavior, emotional instability, playing scold parents 2 years in April 18, 1992 hospitalization. Past history of drug treatment. Check on admission, EEG normal, WBC6.8 × 10 ~ 9 / L, N0.76, L0.24. No abnormalities in body and nervous system examination. Diagnosis of schizophrenia. Clozapine alone treatment system.