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目的观察枸橼酸咖啡因与氨茶碱治疗早产儿呼吸暂停的疗效与安全性。方法选择28~34周出生的出现原发性呼吸暂停1次以上的早产儿78例为研究对象,随机分为观察组与对照组各39例。比较2组患儿治疗72h后临床效果及不良反应发生率。结果用药72h内观察组39例中未发作呼吸暂停37例,有效率94.9%。对照组39例72h内未发作呼吸暂停30例,有效率76.9%。观察组有效率优于对照组,差异有统计学意义(P<0.05)。观察组患儿治疗过程中心动过速、高血糖、喂养不耐受的发生率均低于对照组,差异均有统计学意义(P<0.05)。结论枸橼酸咖啡因治疗早产儿原发性呼吸暂停疗效优于氨茶碱,且不良反应发生率低,值得推广应用。
Objective To observe the efficacy and safety of citrate caffeine and aminophylline in the treatment of apnea in preterm infants. Methods A total of 78 preterm infants with primary apnea who were born between 28 and 34 weeks were randomly divided into observation group (39 cases) and control group (39 cases). The clinical effects and the incidence of adverse reactions in the two groups were compared 72h after treatment. Results 72h observation group of 39 cases without episodes of apnea in 37 cases, the effective rate 94.9%. In the control group, there were 30 cases without apnea in 72 hours, the effective rate was 76.9%. The observation group was better than the control group, the difference was statistically significant (P <0.05). The incidence of tachycardia, hyperglycemia and feeding intolerance in the observation group was lower than that in the control group, the differences were statistically significant (P <0.05). Conclusion Citrate caffeine is superior to aminophylline in the treatment of premature infants with primary apnea, and the incidence of adverse reactions is low, which is worth popularizing and applying.