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目的调查分析成都地区成年男性居民高尿酸血症(hyperuricemia,HUA)患病率及其与代谢综合征(meta-blic syndrome,MS)的关系。方法采集2011年1～5月13002名在四川大学华西医院进行健康体检的男性受检者的疾病史、体格检查及生化指标的测定结果,并进行统计分析。结果成都地区成年男性高尿酸血症的患病率为26.62%,HUA、MS两病共患病率为5.28%。HUA、MS患病率及两病共患病率均随体重指数的增加呈递增趋势。单纯HUA组的年龄、体重指数、收缩压、舒张压、空腹血糖、三酰甘油、胆固醇、低密度脂蛋白均高于正常组(P<0.01),高密度脂蛋白低于正常组(P<0.01);合并组的肌酐、胱抑素C、尿素均高于单纯组(P<0.01)。结论 HUA与MS紧密相关,二者发病过程中的相互加重、促进作用应当引起足够的重视并应进行综合防治。
Objective To investigate the prevalence of hyperuricemia (HUA) and its relationship with metabolic syndrome (MS) in adult male population in Chengdu area. Methods From January to May 2011, 13002 male subjects with healthy subjects in West China Hospital of Sichuan University were collected for disease history, physical examination and biochemical analysis, and statistical analysis was performed. Results The prevalence of hyperuricemia in adult males was 26.62% in Chengdu. The prevalence of HUA and MS was 5.28%. HUA, MS prevalence and co-morbidity rates were increased with the body mass index increased. The body mass index, systolic blood pressure, diastolic blood pressure, fasting blood glucose, triglyceride, cholesterol and low density lipoprotein in HUA group were significantly higher than those in normal group (P <0.01) and high density lipoprotein was lower in normal HUA group (P < 0.01). Creatinine, cystatin C and urea in the combined group were higher than those in the simple group (P <0.01). Conclusions HUA is closely related to MS, and the two of them are aggravating each other in the process of onset, and their promotion should be given sufficient attention and should be comprehensively controlled.