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1943年有人在青霉素的分解产物中发现了青霉胺。1956年试用于治疗肝豆状核变性病,证明能促进体内铜的清除。此后,在长疗程的过程中,证明青霉胺能减少肝内纤维化。1957年又证实青霉胺有分解病理性巨球蛋白的作用。1968年发现此药能抑制原胶原变化为成熟的前胶原。临床应用:1969年有报告用于治疗2例亚慢性肝炎有效。19T1年有报告用青霉胺治疗6例慢性活动性
Penicillin was found in 1943 in the breakdown products of penicillin. 1956 trial for the treatment of Wilson’s disease, proved to promote the removal of copper in the body. Since then, penicillamine has been shown to reduce intrahepatic fibrosis during long courses of treatment. 1957 confirmed that penicillamine has the role of decomposition of pathological macroglobulin. 1968 found that the drug can inhibit the change of procollagen into mature procollagen. Clinical application: 1969 reported for the treatment of 2 cases of sub-chronic hepatitis effective. 19T1 year report with chronic disease board 6 cases of chronic activity