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铂制剂对晚期上皮性卵巢癌是作用最强的药物。联合应用卡铂和顺铂,各有不同的毒性极限量。Land报道应用该方案有极好的前景,但血小板减少症、耳毒性和肾毒性反应仍有较高的发生率。为评价顺铂和卡铂对晚期上皮性卵巢癌妇女联合应用的临床作用和毒性反应,选择FIGO分期为Ⅲ、Ⅳ期,术后病理证实为上皮性卵巢癌,组织学分级2～3级,无手术以外的治疗,Zubrod身体状态评分为0或1,中性粒细胞>1500/mm~3,血小板>100000/mm~3,至少存活二个月。治疗计划28天为一疗程,疗程中第1
Platinum is the most potent drug for advanced epithelial ovarian cancer. Combination of carboplatin and cisplatin, each with a different limit of toxicity. Land reported excellent prospects for using this regimen, but there is still a high incidence of thrombocytopenia, ototoxicity and nephrotoxic response. To evaluate the clinical effect and toxicity of cisplatin and carboplatin in combination with advanced epithelial ovarian cancer women, FIGO staging was selected as stage Ⅲ and Ⅳ, postoperative pathology confirmed epithelial ovarian cancer, histological grade 2 to 3, Without treatment other than surgery, Zubrod scores 0 or 1 for body condition,> 1500 / mm3 for neutrophils,> 100,000 / mm3 for platelets, surviving for at least two months. Treatment plan 28 days for a course of treatment, the first course of treatment