论文部分内容阅读
用放射免疫(双抗体-PEG法)测定109例正常人和85例各种类型肾脏病患者尿液中SIgA含量。表明慢性肾炎普通型、慢性肾炎肾病型活动期和慢性肾炎所引起的慢性肾功能不全均较正常对照组明显增高。慢性肾炎肾病型好转期尿 SIgA与正常对照组无显著差异,但较活动期明显减少。高分子和混合蛋白尿患者尿 SIgA较中分子和低分子蛋白尿患者明显增加。肾病患者24小时尿蛋白排出量与尿 SIgA呈正相关,而与血清 IgA无相关性。文中讨论了非感染性肾脏疾病时尿 SIgA增高的可能原因。
Radioimmunoassay (double antibody-PEG method) was used to measure the SIgA level in urine of 109 healthy individuals and 85 patients with various types of renal disease. That chronic nephritis common type, chronic nephritis and chronic nephritis chronic renal disease caused by chronic renal insufficiency were significantly higher than the normal control group. Chronic nephritis nephropathy urinary SIgA no significant difference with the normal control group, but significantly less than the active phase. Urinary SIgA in patients with both macromolecules and mixed proteinuria was significantly higher than those in patients with moderate and low proteinuria. 24-hour urinary protein excretion in patients with nephropathy was positively correlated with urine SIgA, but not with serum IgA. This article discusses the possible causes of elevated urinary SIgA in non-infectious kidney disease.