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目的:观察复方当归注射液联合常规西药治疗慢性阻塞性肺疾病(COPD)急性加重期肺动脉高压的临床效果。方法:将115例COPD急性加重期合并肺动脉高压患者随机分为对照组55例和观察组60例。对照组给予吸氧、抗感染、解痉、祛痰平喘、纠正酸碱失衡及水、电解质紊乱等西医常规治疗,观察组在对照组治疗的基础上给予复方当归注射液穴位注射,2组均观察治疗7天。观察治疗前后2组患者临床症状的改善情况,检测血液酸碱度(pH)、动脉血二氧化碳分压(PaCO2)、动脉血氧分压(PaO2)及血流动力学指标的变化情况。结果:治疗后,2组患者的血液pH、PaO2、左心室射血分数(LVEF)均较治疗前有所升高(P<0.05),PaCO2、肺动脉收缩压(PASP)、肺动脉舒张压(PADP)、平均肺动脉压(MPAP)均较治疗前有所降低(P<0.05),2组以上各指标比较,差异均有显著性意义(P<0.05)。结论:复方当归注射液联合常规西药治疗慢性阻塞性肺疾病急性加重期肺动脉高压患者,能有效改善患者的临床症状,降低肺动脉压,标本兼治,临床效果满意。
Objective: To observe the clinical effect of Fufang Danggui injection combined with conventional western medicine in treating pulmonary hypertension in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods: A total of 115 patients with acute exacerbation of COPD and pulmonary hypertension were randomly divided into control group (55 cases) and observation group (60 cases). The control group was given routine treatment of Western medicine such as oxygen, anti-infective, antispasmodic, expectorant and antiasthmatic, acid-base imbalance correction and water and electrolyte disturbances. The observation group was given Compound Danggui Injection acupoint injection on the basis of the control group. All patients were observed for 7 days. The improvement of clinical symptoms in both groups before and after treatment was observed. The changes of blood pH, PaCO2, PaO2 and hemodynamics were measured. Results After treatment, the blood pH, PaO2 and LVEF in both groups were significantly higher than those before treatment (P <0.05), PaCO2, PASP, PADP ), And mean pulmonary artery pressure (MPAP) were lower than those before treatment (P <0.05). There was significant difference in each index between two groups (P <0.05). Conclusion: Compound Danggui injection combined with conventional western medicine can effectively improve the clinical symptoms and reduce pulmonary arterial pressure in patients with acute exacerbation of chronic obstructive pulmonary disease, and the clinical effect is satisfactory.