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作者发现系统性红斑狼疮(SLE)患者,在急性期可发生可逆性低氧血症,认为后者与血浆中补体裂解产物浓度增高有关。病人和方法均符合美国风湿病协会 SLE活动期的诊断标准,排除间质性肺病及胸片上有肺实质浸润及感染患者。患者分Ⅰ组:住院的活动性 SLE,肺泡-动脉(A-a)氧梯度异常,入院时胸片无肺实质浸润;Ⅱ组:住院的活动性SLE,A-a 氧梯度正常,胸片无肺实质浸润;Ⅲ组:门诊的稳定型 SLE 患者;Ⅳ组:正常对照志
The authors found that patients with systemic lupus erythematosus (SLE) can develop reversible hypoxemia in the acute phase, which is thought to be associated with increased concentrations of complement cleavage products in plasma. Patients and methods are in line with the American College of Rheumatology SLE active diagnostic criteria to rule out interstitial lung disease and lung parenchymal infiltration and infection in patients. Patients were divided into group Ⅰ: hospitalized active SLE, abnormal alveolar-artery (Aa) oxygen gradient, no pulmonary parenchymal infiltration on chest X-ray at admission; Ⅱ group: hospitalized active SLE, normal oxygen gradient Aa, ; Group Ⅲ: outpatient stable SLE patients; group Ⅳ: normal control