为寻求具有较高生物活性的农药新品种,以杀螨剂pyflubumide为先导,在其母体结构中引入肟酯和二芳基醚结构,设计并合成了7个未见文献报道的1H-吡唑-4-肟酯乙酰胺类化合物,其结构均经核磁共振氢谱、质谱和元素分析确证。初步生物活性测试结果表明,在500 mg/L质量浓度下,所有目标化合物对朱砂叶螨Tetranychus cinnabarinus均有较强的杀灭作用,大部分化合物对其的致死率达100%,但药效低于对照药剂阿维菌素和炔螨特。 In order to search for a new pesticide with higher biological activity, pyrelubimide was taken as the guide and oxime ester and diaryl ether structures were introduced into its parent structure. Seven novel 1H-pyrazoles -4-oxime ester acetamides, whose structures were confirmed by 1H NMR, MS and elemental analysis. The preliminary bioassay results showed that all the target compounds had a strong killing effect on Tetranychus cinnabarinus at the concentration of 500 mg / L, most of the compounds had a lethality of 100%, but the efficacy was low In the control drug abamectin and propargite special.