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目的 探讨血清磷酸化酶a活性对评价TNT早期肝损伤的意义。方法 测定TNT接触组、慢性乙型肝炎患者和慢性HBsAg携带组血清磷酸化酶a活性。结果 TNT生产车间空气中TNT浓度均超过国家最高容许浓度 (MAC =1mg/m3) ,工人皮肤污染较严重。TNT接触组和慢性乙型肝炎患者血清磷酸化酶a活性与对照组比较无差异。结论 推测接触组血清磷酸化酶a活性的升高可能与TNT所致肝损伤有一定关系。如果TNT作业工人乙型肝炎病毒血清学标志为阴性 ,建议用其血清磷酸化酶a活性升高作为评价TNT早期肝损伤的指标。
Objective To investigate the significance of serum phosphorylase-a activity in evaluating early liver injury in TNT. Methods Serum phosphorylase-a activity in TNT-exposed group, chronic hepatitis B patients and chronic HBsAg-carrying group was measured. Results The concentration of TNT in the air of TNT workshop exceeded the national maximum allowable concentration (MAC = 1mg / m3), and workers’ skin was more polluted. There was no difference in serum phosphorylase-a activity between TNT exposure group and chronic hepatitis B patients compared with control group. Conclusion It is speculated that the increase of serum phosphorylase-a activity in contact group may be related to the liver damage caused by TNT. If a TNT worker has a negative serological marker for hepatitis B virus, it is advisable to use elevated serum phospholase a as an indicator of early liver damage in TNT.