微生物可引起急性感染与持续性感染。构成持续性感染的机制包括:病毒基因整合,病毒基因的表达被修饰或被抑制,病原微生物抑制宿主免疫应答及宿主遗传因素等。文章针对持续性感染这一“老问题”提出了一些研究的建议,包括研究感染与发病的关系,研发治疗性疫苗或联合应用免疫调节剂,以及多做系统性研究与发展基础与临床合作以实现学科间交叉。 Microbes can cause acute and persistent infections. Mechanisms that make a persistent infection include viral gene integration, modification of the viral gene’s expression or inhibition, inhibition of the host’s immune response by the pathogenic microorganism and host genetic factors. In this paper, we propose some research proposals for the “old problem” of persistent infection, including researching the relationship between infection and disease, developing therapeutic vaccine or combination immunomodulator, and doing more systematic research and development of basic and clinical Cooperation to achieve interdisciplinary.