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目的:探究对动脉粥样硬化应用不同剂量阿托伐他汀的临床效果。方法:临床纳入2014年10月~2016年5月在我院进行治疗的动脉粥样硬化患者88例,按随机投掷法进行分组,高剂量组44例给予20mg阿托伐他汀进行治疗,低剂量组44例给予10mg阿托伐他汀进行治疗,对比两组并发症发生几率及实验室检查结果。结果:治疗后高剂量组总胆固醇、动脉内膜中层厚度、高密度脂蛋白、甘油三酯、高密度脂蛋白胆固醇水平相比低剂量组得到明显好转,P<0.05。治疗后高剂量组发生脑梗死、斑块面积增大、神经衰弱、脑血管疾病、心律失常几率相较低剂量组均有所下降,P<0.05。结论:通过应用高剂量的阿托伐他汀可改善治疗质量,降低并发症的发生率。
Objective: To investigate the clinical effect of different doses of atorvastatin on atherosclerosis. Methods: A total of 88 patients with atherosclerosis who were treated in our hospital from October 2014 to May 2016 were randomly divided into two groups: randomized throwing method, 44 patients in the high-dose group received atorvastatin 20mg, low-dose Group 44 cases were given atorvastatin 10mg for treatment, compared the incidence of complications in both groups and laboratory test results. Results: After treatment, total cholesterol, arterial intima-media thickness, high-density lipoprotein, triglyceride and high-density lipoprotein cholesterol levels in high-dose group were significantly improved compared with low-dose group, P <0.05. After treatment, cerebral infarction, plaque enlargement, neurasthenia, cerebrovascular disease and arrhythmia were all decreased in high dose group compared with low dose group (P <0.05). Conclusions: The use of high-dose atorvastatin improves the quality of treatment and reduces the incidence of complications.