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目的了解抗!2-糖蛋白Ⅰ抗体(抗!2-GPⅠ抗体)与系统性红斑狼疮(SLE)临床特点的关系及在其诊断中的价值。方法采用酶联免疫吸附试验(ELISA)检测112例SLE患者、40例类风湿关节炎(RA)患者、30例干燥综合征(SS)患者和40名正常人血清中的抗!2-GPⅠ抗体水平。同时,测定患者血清中的抗心磷脂抗体(ACL)等指标,并分析其与患者的临床特点(如:血栓、流产)的关系及其临床意义。统计学分析采用t检验、!2检验和Spearman检验。结果抗!2-GPⅠ抗体在SLE中敏感性为21.4%(24/112),特异性为88.6%,在RA和SS敏感性分别为15.0%(6/40)和6.7%(2/30),40名正常对照均为阴性。抗!2-GPⅠ抗体与血栓形成密切相关(P<0.01),与ACL-IgG和IgM型水平呈正相关(r=0.479,P=-0.032;r=0.400,P=0.045)。抗!2-GPⅠ抗体与其他临床及实验室指标无明显相关性。结论抗!2-GPⅠ抗体在SLE中具有一定的敏感性,且可能在SLE的血栓形成中发挥作用,联合检测ACL与抗!2-GPⅠ抗体能够辅助诊断SLE伴血栓形成。
Objective To investigate the relationship between the anti-2-glycoprotein Ⅰ antibody (anti-2-GPⅠ antibody) and the clinical features of systemic lupus erythematosus (SLE) and its value in the diagnosis. Methods Serum anti-2-GPⅠ antibodies in 112 patients with SLE, 40 patients with rheumatoid arthritis (RA), 30 patients with Sjögren’s syndrome (SS) and 40 normal individuals were detected by enzyme linked immunosorbent assay (ELISA) Level. At the same time, the serum anticardiolipin antibodies (ACLs) and other indicators were measured and their clinical characteristics (such as thrombosis, abortion) and their clinical significance were analyzed. Statistical analysis using t test, 2 test and Spearman test. Results The sensitivity of anti-2-GPⅠ antibody in SLE was 21.4% (24/112), specificity was 88.6%, and sensitivity in RA and SS was 15.0% (6/40) and 6.7% (2/30) , 40 normal controls were negative. The anti-2-GPⅠantibody was closely related to thrombosis (P <0.01), and positively correlated with the level of ACL-IgG and IgM (r = 0.479, P = -0.032; r = 0.400, P = 0.045). Anti-2-GP Ⅰ antibody and other clinical and laboratory indicators no significant correlation. Conclusion Anti-2-GPⅠ antibody has some sensitivity in SLE and may play a role in thrombosis of SLE. Combined detection of ACL and anti-2-GPⅠ antibody can help diagnose SLE with thrombosis.