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降压治疗降低了糖尿病(DM)患者的心血管事件发生率。但是,该治疗对亚临床动脉粥样硬化的作用尚未明确。TART(曲格列酮动脉样硬化逆转试验)是一项在胰岛素依赖性2型DM成年患者中评估曲格列酮治疗对颈动脉内膜中层厚度(CIMT)进展影响的随机试验。本文报道对TART试验中降压治疗和CIMT相关性的事后队列分析的结果。
Antihypertensive therapy reduces the incidence of cardiovascular events in patients with diabetes mellitus (DM). However, the effect of this treatment on subclinical atherosclerosis has not been clarified. The TART (Troglitazone Atherosclerosis Reversal Test) is a randomized trial evaluating the effect of troglitazone on the progression of carotid intima-media thickness (CIMT) in insulin-dependent type 2 DM adults. This article reports the results of a post hoc cohort analysis of the association between antihypertensive therapy and CIMT in the TART trial.