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目的观察小剂量尿激酶联合羟乙基淀粉治疗进展性脑梗死的有效性和安全性。方法选择进展性脑梗死患者127例随机分为治疗组67例,对照组60例。对照组用常规治疗方法(抗血小板聚集、活血化瘀等)。治疗组在常规治疗的基础上加用羟乙基淀粉和尿激酶。分别于5d、7d和14d进行疗效评定。结果治疗组控制率85.1%,对照组控制率48.3%,2组间比较差异有统计学意义(P<0.05)。结论小剂量尿激酶联合羟乙基淀粉治疗进展性脑梗死安全有效。
Objective To observe the efficacy and safety of low-dose urokinase combined with hydroxyethyl starch in the treatment of patients with progressive cerebral infarction. Methods 127 patients with progressive cerebral infarction were randomly divided into treatment group (67 cases) and control group (60 cases). Control group with conventional treatment methods (anti-platelet aggregation, blood circulation, etc.). Treatment group in the conventional treatment based on the addition of hydroxyethyl starch and urokinase. The curative effect was evaluated on 5d, 7d and 14d respectively. Results The control rate was 85.1% in the treatment group and 48.3% in the control group. There was significant difference between the two groups (P <0.05). Conclusion Low-dose urokinase combined with hydroxyethyl starch is safe and effective in treating progressive cerebral infarction.