文报道1例41岁自感乏力的女性患者,通过对其各类内分泌激素基础值和动态功能测定以及糖皮质激素受体分析,证实为一例原发性皮质醇拮抗症(PCR)。结合文献资料和本例观察结果,初步认为PCR具有异质性,按照受体异常的性质和程度可有不同的临床类型,并且对人工合成和天然的糖皮质激素又表现出不同的敏感性。 We report a case of primary cortisol antagonism (PCR) in a 41-year-old woman with self-induced fatigue who was tested for basal and dynamic endocrine function and glucocorticoid receptor analysis. Based on the literature data and the observed results of this case, PCR is initially considered to be heterogeneous and may have different clinical types according to the nature and extent of the abnormality of the receptor, and exhibit different sensitivities to synthetic and natural glucocorticoids.