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异搏定不良反应的发病率约为9%.在心血管系统方～26 h内消失.面有抑制心肌收缩力,扩张血管.导致低血压,心动过缓,未给异搏定的病人或动物,静脉补钙后的正性肌力作房室传导阻滞等.大多为剂量依赖性,减量后可消失.用持续不超过15min;而应用异搏定治疗的过程中.同样静脉补钙可部分逆转异搏定对血液动力学的影响.在途径相同剂量的钙剂对心肌收缩力的影响可持续45 min狗的研究中发现.血清钙浓度增至3.25 mmol·L~(-1)可消除左右.据此.可以认为钙剂能逆转异搏定所致的心肌收缩异搏定对心肌收缩力、心排出量和血压的抑制作用.但此浓度对电生理的改变不明显.进一步提高血清钙含量可减轻异搏定造成的房室传导阻滞,对窦性心动过缓却不能逆转.有报道服用5.6g异搏定患者出现的高度房室传导阻滞.经支持疗法及静脉注射葡萄糖酸钙后,传导阻滞在24
Verapamil incidence of adverse reactions was about 9% in the cardiovascular system ~ 26 h disappear side surface inhibition of myocardial contractility, dilation of blood vessels lead to hypotension, bradycardia, not given to patients with verapamil or animals , Intravenous calcium after positive for atrioventricular block, etc. Mostly dose-dependent, can disappear after reduction with sustained no more than 15min; and the application of verapamil in the treatment of the same intravenous calcium can Partial reversal of verapamil on hemodynamics in the same way the same dose of calcium on myocardial contractility can continue for 45 min dogs found in the study.Serum calcium concentration increased to 3.25 mmol·L -1 Therefore, it can be considered that calcium can reverse the verapamil-induced myocardial contractility on myocardial contractility, cardiac output and blood pressure inhibition.But the concentration of electrophysiological changes was not obvious. Serum calcium can reduce the verapamil caused by atrioventricular block, sinus bradycardia but can not be reversed.Have reported taking 5.6g verapamil patients with a high degree of atrioventricular block.After supportive therapy and intravenous injection After calcium gluconate, conduction block at 24