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目的通过对糖尿病肾病(DN)患者的糖化血红蛋白(HbAlc)、血清胱抑素C(Cys C)和尿微量白蛋白(UmAlb)水平变化的检测,探讨三者联合检测对DN的重要诊断意义。方法选取本院住院2型糖尿病(T2DM)患者319例,据患者是否合并肾病分为DN组、T2DM组,并按HbAlc水平将DN组分为A、B、C、D组;另选健康体检者52例,作为正常对照组。采用离子交换高压液相法测定HbAlc,采用乳胶颗粒增强免疫比浊法测定Cys C和U-mAlb水平。结果不同HbAlc水平组和正常对照组两两比较,T2DM组、DN组与正常对照组比较,DN组与T2DM组比较,HbAlc、Cys C和U-mAlb水平均有统计学意义(P<0.01)。相关性分析表明,HbAlc和Cys、U-mAlb水平均呈正相关(r=0.412,P<0.05;r=0.479,P<0.05)。结论 HbAlc、Cys C和U-mAlb水平可以作为诊断DN的重要指标,联合检测三者对DN的诊断具有重要意义。
Objective To investigate the significance of the combination of the three tests in the diagnosis of DN in patients with diabetic nephropathy (DN) by detecting the levels of HbAlc, Cys C and UmAlb. Methods 319 patients with type 2 diabetes mellitus (T2DM) admitted to our hospital were divided into DN group and T2DM group according to whether they had nephropathy or not, and divided into DN group A, B, C and D according to HbAlc level. 52 cases, as a normal control group. HbAlc was determined by ion-exchange high-pressure liquid-phase method. Cys C and U-mAlb levels were measured by latex particle-enhanced immunoassay. Results The levels of HbAlc, Cys C and U-mAlb were significantly different between DN group and T2DM group in T2DM group and DN group compared with the control group (P <0.01) . Correlation analysis showed that HbAlc and Cys, U-mAlb levels were positively correlated (r = 0.412, P <0.05; r = 0.479, P <0.05). Conclusion The levels of HbAlc, Cys C and U-mAlb can be used as an important index in the diagnosis of DN. The combined detection of these three is of great significance for the diagnosis of DN.