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巨噬细胞和肾小球系膜细胞均有合成白介素Ⅰ〔IL-I〕的能力,但两者在AGBM·GN时的IL-I生成中所起的作用尚不清楚。作者通过动物实验对被动性AGBM-GN的自体反应相(巨噬细胞依赖的〔PAGBM GN〕)和异体反应相(非巨噬细胞依赖的)IL-1水平进行了定量研究,以了解肾小球巨噬细胞浸润在AGBM GN中的意义。将40只新西兰大白兔(体重2-2.5kg)分为四组进行研究。Ⅰ组、巨噬细胞依赖的PAGBM GN模型(7只)。先注射羊抗兔GBM球蛋白(48mg/kg、iv),16小时后给予兔抗羊球蛋白(75mg/kg,iv),分别在8、16小时后再追加2次兔抗羊球蛋白;Ⅱ组:非巨噬细胞依赖的异体反应相
Both macrophages and glomerular mesangial cells have the ability to synthesize interleukin I [IL-I], but the role of both in IL-I production at AGBM-GN remains unclear. The authors conducted a quantitative study of the auto-reactive phase (macrophage-dependent [PAGBM GN]) and alloreactive phase (non-macrophage-dependent) IL-1 levels of passive AGBM-GN in animal experiments to understand the role of kidney Significance of ball macrophage infiltration in AGBM GN. 40 New Zealand white rabbits (body weight 2-2.5kg) were divided into four groups to study. Group Ⅰ, macrophage-dependent PAGBM GN model (n = 7). Rabbit anti-rabbit GBM globulin (48 mg / kg, iv) was injected first and rabbit anti-sheep globulin (75 mg / kg, iv) was given 16 hours later. Rabbit anti-sheep globulin was additionally added after 8 and 16 hours, Group II: non-macrophage-dependent allogenic phase