利用生物可降解高分子材料包埋化疗药物制成控释剂型颅内植入后 ,在脑瘤局部定点化疗 ,可绕过血脑屏障 ,极大地提高瘤内药物浓度 ,同时降低身体其它部位的药物浓度。本文从聚合物材料、制备方法、植入方法、释药机理及药物体内分布、瘤内化疗等方面综述了近年来颅内植入剂的进展。 The use of biodegradable polymer embedding chemotherapy drugs made of controlled release formulations of intracranial implantation in the local brain tumor chemotherapy can bypass the blood-brain barrier, greatly enhance the drug concentration in the tumor while reducing the body’s other parts of the Drug concentration. In this paper, the progress of intracranial implants in recent years is reviewed in terms of polymer materials, preparation methods, implantation methods, drug release mechanism and drug distribution in vivo, and intratumoral chemotherapy.