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A series of new aurone derivatives was prepared by means of a practical route and their anti-vascular smooth muscle cells(VSMC) vegetation activities were evaluated by the 3-(4,5-dimethylthlazol-2-yl)-2,5diphenyltetrazolium bromide(MTT) method with tetrandrine as a positive contrast drug.The structures of the compounds were confirmed by 1 H NMR,13 C NMR and electrospray ionization mass spectrometry(ESI-MS).Several new compounds exhibited promising activity against VSMC proliferation and the preliminary structure-activity relationships(SAR) were discussed in order to investigate the essential structures required for their bioactivities.
A series of new aurone derivatives was prepared by means of a practical route and their anti-vascular smooth muscle cells (VSMC) vegetation activities were evaluated by the 3- (4,5-dimethylthlazol-2-yl) -2,5diphenyltetrazolium bromide MTT) method with tetrandrine as a positive contrast drug. The structures of the compounds were confirmed by1H NMR, 13C NMR and electrospray ionization mass spectrometry (ESI-MS). Several new compounds exhibits promising activities against VSMC proliferation and the preliminary structure -activity relationships (SAR) were discussed in order to investigate the essential structures required for their bioactivities.