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方法:334例原发性高胆固醇血症,分两组:组1,血清总胆固醇240～300mg/dl,口服Lovastatin20mg睡前服(53例),或吉非罗齐(Gemfibrozil)600mg每日2次(56例);组2,血清总胆固醇>300mg/dl,口服Lova- statin 40mg睡前服(114例),或吉非罗齐600mg每日2次(111例)。如治疗6周后血清总胆固醇仍>200mg/dl,则Lovastatin剂量加倍,吉非罗齐始终不变。治疗12周时Lovastatin剂量组1平均每日38.5mg,组2每日77.4mg。结果:治疗12周后,Lovastatin使组1血清总胆固醇下降23％,组2下降34％;组1 LDL胆固醇下降31％,组2下降42％。吉
Methods: 334 cases of primary hypercholesterolemia were divided into two groups: group 1, serum total cholesterol 240 ~ 300mg / dl, oral administration of 20mg lovastatin before bedtime (53 cases) or gemfibrozil 600mg daily (56 cases); group 2, serum total cholesterol> 300 mg / dl, oral administration of 40 mg of Lova-statin before bedtime (114 cases), or gemfibrozil 600 mg twice daily (111 cases). If 6 weeks after treatment of serum total cholesterol is still> 200mg / dl, Lovastatin dose doubled, gemfibrozil unchanged. At 12 weeks of treatment, Lovastatin dose group 1 averaged 38.5 mg daily and group 2 received 77.4 mg daily. RESULTS: After 12 weeks of treatment, Lovastatin decreased serum total cholesterol by 23% in group 1 and by 34% in group 2, by 31% in group 1 and by 42% in group 2. Ji