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作者检查了34例可疑骨髓增生异常综合征(DMS)病人的造血细胞体外生长方式,并与正常BFU-E和CFU-C进行比较。正常人每2×10~5平皿单个核骨髓细胞的BFU-E和CFU-C集落数分别为68±I4.76和53.6±9.2。6例BFU-E和CFU-C生长正常的病人中没有1例最后确诊为DMS。并在50个月随访观察中,没有1例进展为明显的白血病。因此,骨髓细胞培养是一项除外DMS和其他一些白血病前期疾病的有意义检查。剩下的28例病人有不同程度的生长异常,每个细胞系波动在0至集落数低限之间。其中有7例病人最终诊断为非DMS的疾病。这些疾病一部分认为是白血病前期,但不包括在DMS之中。如Fanconi氏贫血。这表明体外造血细胞数目减低,在某些不同的血液病中是常见的。
The authors examined the in vitro growth of hematopoietic cells in 34 patients with suspected myelodysplastic syndrome (DMS) and compared them to normal BFU-E and CFU-C. Normal BFU-E and CFU-C colonies per 2 × 10 ~ 5 plates of single nuclear bone marrow cells were 68 ± I4.76 and 53.6 ± 9.2.6 cases of normal BFU-E and CFU-C patients did not grow One case was finally diagnosed as DMS. And at the 50-month follow-up observation, none of the patients progressed to overt leukemia. Therefore, bone marrow cell culture is a meaningful check except for DMS and other pre-leukemias. The remaining 28 patients had varying degrees of growth abnormalities, with each cell line fluctuating between 0 and the lowest number of colonies. Seven of these patients eventually diagnosed as non-DMS disease. Some of these diseases are considered to be pre-leukemia, but not included in the DMS. Such as Fanconi’s anemia. This indicates a decrease in the number of hematopoietic cells in vitro and is common in some different blood diseases.