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慢性骨髓炎是一种常见疾病。骨髓炎传统治疗疗程是在彻底清创后使用4~6周的静脉注射抗生素治疗。然而，并没有确凿的证据证实，这一疗程相较于其他疗程的抗生素治疗具有优越性。近年来，随着对该疾病的认识愈发深入，各项治疗技术不断发展，抗生素的使用方案也发生了改变。本文就慢性骨髓炎抗生素应用疗程的最新进展作一综述。“,”Chronic osteomyelitis is a common disease. Traditionally, osteomyelitis is treated with parenteral antibiotics for 4 to 6 weeks after thorough debridement. However, this antibiotic treatment course has no documented superiority over other courses of antibiotic treatment. As this disease has been understood more deeply and various treatment technologies have been explored recently, the use of antibiotics has also changed. This article reviews the latest progress concerning the course of antibiotic treatment for chronic osteomyelitis.